OUR SOLUTION | MelioOneⓇ
How does MelioOne® work?
MelioOne® uses a proven polymer-based technology that enables sustained and local drug release directly at the site of inflammation. The dosage amount released in 12 months is equivalent to one Ibuprofen 400 pill and prevents systemic side effects from oral pain medication consumption.
Oral painkillers (NSAIDs) and Intrauterine Devices (IUDs) for period pain management
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, and diclofenac are widely recognized as effective treatments for primary dysmenorrhea. These medications alleviate menstrual pain by inhibiting prostaglandin synthesis, thereby reducing uterine contractions and associated discomfort.
Clinical studies have demonstrated that NSAIDs are effective in managing period pain. Most over-the-counter pain killers work by blocking prostaglandin production, and many studies have shown that they can reduce menstrual pain effectively.
In recent years, intrauterine devices (IUDs) have gained traction not only for contraception but also as a delivery format for managing period-related symptoms. With an efficacy rate of over 99% in preventing pregnancy, the IUD format is backed by decades of clinical use and is widely regarded as safe and reliable.
Its key advantage lies in its long-acting nature — once inserted, it can remain in place for several years with minimal effort required from the patient. This format ensures consistent local delivery, avoids daily adherence issues, and supports user convenience, making it an ideal platform for sustained therapeutic applications beyond contraception.
How is MelioOne® different from existing IUDs?
Conventional intrauterine devices (IUDs) are primarily designed for contraception and are categorized into hormonal and non-hormonal types. Hormonal IUDs, such as those releasing levonorgestrel, are associated with side effects including ovarian cyst formation, mood alterations, and weight fluctuations. Notably, approximately 12% of users may develop ovarian cysts during usage. Conversely, non-hormonal copper IUDs, while hormone-free, are linked to increased menstrual bleeding and intensified period cramping. Studies indicate that up to 70% of users experience heavier bleeding, and 60% report increased period cramping during the initial months post-insertion.
MelioOne® distinguishes itself by utilizing the IUD format not for contraception but as a delivery system for nonsteroidal anti-inflammatory drugs (NSAIDs) directly to the uterus. This targeted approach aims to alleviate menstrual pain effectively while minimizing systemic exposure and avoiding hormonal side effects. MelioOne® works by normalizing (i.e., reducing) prostaglandin production in the uterus, bringing down inflammation during menstruation and thereby reducing pain. By eschewing hormonal components, MelioOne® offers a therapeutic option for individuals who prefer not to use hormonal IUDs due to medical contraindications, providing a novel solution for period pain management.
How does MelioOne® reduce systemic side-effects from NSAIDs?
Oral NSAIDs require sustained high systemic concentrations to effectively manage menstrual pain, as the medication must circulate through the bloodstream to reach the uterus. This systemic delivery can lead to fluctuations in drug levels and often necessitates repeated dosing, increasing the risk of side effects such as gastrointestinal discomfort and cardiovascular strain. Furthermore, the drug concentration is high in organs such as the stomach (where the drug is absorbed), the liver (where it first passes through), and the kidneys (where a large portion of the blood circulates through).
MelioOne® takes a different approach: by delivering NSAIDs directly into the uterus, we capitalize on the uterine first-pass effect, where drugs administered locally achieve higher concentrations while minimizing systemic absorption, allowing us to target the source of pain more precisely. This local administration reduces the need for high systemic doses, helping to minimize undesired side effects while maintaining therapeutic efficacy where it matters most.